Drug Summary

Methylprednisolone (Solumedrol®)

Pharmacologic properties:

Methylprednisolone is a systemic corticosteroid that has many downstream effects on the body. Therapeutically, it has potent anti-inflammatory properties. The onset of action is several hours.


  • Acute exacerbation of asthma/COPD
  • Anaphylaxis/ Acute allergic reactions


  • Known hypersensitivity


  • Use caution when administering to patients with diabetes mellitus, pregnancy, liver disease, or signs of systemic infection
  • Do not administer methylprednisolone preserved with benzyl alcohol to pregnant women, breast feeding women, or neonates - benzyl alcohol is associated with serious adverse events in this population

Adverse Reactions:

  • Adverse effects with single bolus use of Solumedrol are uncommon, although patients on chronic steroids are at risk for a multitude of side effects

Dosage and administration:

  • Adult
    • 125 mg IV
  • Pediatric
    • 2 mg/kg IV/IM (maximum dose 60 mg)