Drug Summary

Thiamine Hydrochloride

Pharmacologic properties:

Thiamine is vitamin B1, a cofactor needed for the utilization of glucose. Chronic alcohol abuse interferes with intake, absorption, and utilization of thiamine. Thiamine deficiency can lead to Wernicke’s encephalopathy (ophthalmoplegia, ataxia, and confusion) or Korsakoff’s syndrome (amnesia, confabulation, and impaired memory).

Indications:

  • Altered mental status (especially in alcoholic patient)
  • Wernicke’s encephalopathy or Korsakoff’s syndrome
  • Delirium Tremens (DT’s)
  • Malnourishment

Contraindications:

  • Known hypersensitivity

Precautions:

  • Should be given prior to the administration of D50 because administration of glucose may precipitate acute symptoms of thiamine deficiency in marginally nourished subjects

Adverse Reactions:

  • Anaphylaxis
  • Hypotension

Dosage and administration:

  • 100 mg IV