Thiamine is vitamin B1, a cofactor needed for the utilization of glucose. Chronic alcohol abuse interferes with intake, absorption, and utilization of thiamine. Thiamine deficiency can lead to Wernicke’s encephalopathy (ophthalmoplegia, ataxia, and confusion) or Korsakoff’s syndrome (amnesia, confabulation, and impaired memory).
- Altered mental status (especially in alcoholic patient)
- Wernicke’s encephalopathy or Korsakoff’s syndrome
- Delirium Tremens (DT’s)
- Should be given prior to the administration of D50 because administration of glucose may
precipitate acute symptoms of thiamine deficiency in marginally nourished subjects
Dosage and administration: